The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...

In 2021, a technology developed at University of Michigan, called Seq-Scope, revolutionized the ability to map gene activity within intact tissue at microscopic resolution, enabling researchers to ...

One of oncology's biggest challenges is that the same treatment can work well for some patients but fail completely in others. A study published in Nature Communications, by a multidisciplinary team ...

A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that ...

Bone remodeling is a dynamic and tightly regulated process that maintains skeletal integrity throughout life. Central to this process are osteoclasts, the ...

Use of ultra-sensitive whole genome circulating tumor DNA detection to predict early recurrence in high-risk localized RCC after nephrectomy: Preliminary real-world findings. Forty-two genes ...

Christopher H. Contag explores how tissue regeneration involves organized interactions beyond just cell replacement, highlighting two emerging technologies ...

Over the past two decades, cell biologists and computational biologists have worked to develop lineage tracing techniques that can decode the ...

A team led by HHMI Hanna Gray Fellow Shan Meltzer has created a detailed, cell-by-cell map of the spinal cord that offers a new framework for understanding chronic pain and provides a powerful new ...