本综述系统阐述了猫和狗体内谷胱甘肽转移酶（GSTs）的多样性、结构与功能，揭示了其与人类在GST基因表达（如GSTM和GSTT）上的显著差异，强调了物种特异性对异源物解毒（xenobiotic detoxification）和毒性风险调控的重要性。 Abstract 谷胱甘肽化（Glutathionylation）是一 ...

Figure 1: Translation inhibition using toxin or RNAi induces xenobiotic detoxification. Figure 2: Translation defects in the germline induce a systemic xenobiotic detoxification response. Figure 3: ...

Lifespan extension is undeniably interesting, delving into the fundamental questions of what determines the expiration date of our cells (and our bodies). Research has found various genetic ...

A mutant worm with a change in one mitochondrial gene produces more reactive oxygen species (ROS), which can be harmful to cells by causing oxidative stress. However, this mutant worm is able to live ...

Vanda Gunning, Kyriakos Tzafestas, Helen Sparrow, Emily J. Johnston, Andrew S. Brentnall, Jennifer R. Potts, Elizabeth L. Rylott and Neil C. Bruce The explosive 2,4,6-trinitrotoluene (TNT) is a major ...

Hepatic hydroxylation is an essential step in the metabolism and excretion of bile acids and is necessary to avoid pathologic conditions such as cholestasis and liver damage. In this report, we ...

Efficacy of repeated injections of CLR 131 (I-131-CLR1404) in a MES SA/Dx5 athymic nude mouse model. This is an ASCO Meeting Abstract from the 2017 ASCO Annual Meeting I. This abstract does not ...

Mutation in mitochondrial gene doubles the lifespan in the worm C. elegans by turning on a detox pathway, researchers report. A mutant worm with a change in one mitochondrial gene produces more ...