Among the large, diverse set of mammalian long noncoding RNAs (lncRNAs), long noncoding primary microRNAs (lnc-pri-miRNAs) are those that host miRNAs. Whether lnc-pri-miRNA loci have important ...

PHILADELPHIA -- Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does ...

Study links exosomal microRNA to ventricular remodelling in heart failure. Discover how this biomarker could inform future ...

microRNAs (miRNAs) are essential regulators of gene expression in diverse biological processes and disease states. They are short 22-nt noncoding RNAs that bind to mRNA targets via partial base ...

Potential of Field Is Catalyst for Emerging Diagnostic and Therapeutic Strategies As key regulators of gene expression and cellular machinery, microRNAs may be the most significant discovery in ...

A research team led by scientists from the Hong Kong University of Science and Technology (HKUST) has revealed how secondary structure RNA elements control the cleavage activity of the DICER enzyme in ...

MicroRNAs—as an entirely new class of gene-expression regulators (discovered in humans in 2001)—have elicited widespread interest. These noncoding, single-stranded, 20 to 25 nucleotide RNAs regulate ...

microRNAs (miRNA), non-coding RNA molecules, are widely known for regulating mRNA stability and translation. miR-10b has been increasingly implicated in the pathogenesis of gliomas, cancers of the ...

The 2024 Nobel Prize in Physiology or Medicine was awarded to Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA and its pivotal role in post-transcriptional gene regulation.