Short stature and gonad failure can be a severe side effect of the conditioning protocol used before hematopoietic cell transplantation (HCT). The final height after HCT is not reduced in patients ...

The gonad arises as a bipotential organ primordium. Expression of the Y-linked gene, Sry, in the bipotential gonad leads to the differentiation of Sertoli cells, which orchestrate testis development.

A preliminary study by a Wuhan medical team found the first clinical evidence the novel coronavirus (COVID-19) infection could harm male gonad functions by significantly increasing sex hormones.