Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most protein-coding genes with humans, their regulatory ...

Mice carrying a gene variant present in nearly every human on Earth — but not in extinct relatives including Neanderthals — produce more-complex chirps than normal rodents do 1. The finding suggests ...

TECHNO: A two-step genome editing strategy that enables efficient replacement of entire mouse loci with full-length human genes to generate gene-humanized mice.

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most protein-coding genes with humans, their regulatory ...

A new contender for a human 'language gene' can change the way that mice squeak when it is incorporated into their DNA. The gene is called NOVA1, and in our own species, it is remarkably unique. While ...

Scientists have developed six lines of humanized mice that can serve as valuable models for studying human cases of COVID-19. Scientists at La Jolla Institute for Immunology (LJI) have developed six ...

In an important step toward more effective gene therapies for brain diseases, researchers have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier ...

Researchers have described the development of a novel murine model of glioblastoma established with a patient-derived xenograft (PDX) in humanized mice that harbored an almost complete human immune ...