Covalent inhibitors are a specialized class of small molecules designed to form chemical bonds with their target proteins, often resulting in prolonged target engagement and enhanced potency. The ...

The Flagship Pioneering spinout uses permanent bonds to target shallow pockets, drastically expanding the druggable universe for small molecules.

Numerous applications of phenolic compounds, a large family of naturally occurring molecules, in biosensing, bioimaging, and disease treatment can not be ...